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As per ResNo466, ResNo446, and OSNo001, Brazil has a centralized registration process for ethics committees (ECs) and requires institutional level EC approval for each trial site.The National Research Ethics Commission (Comisso Nacional de tica em Pesquisa (CONEP)) is the central body responsible for coordinating the network of institutional ECs, The EPAs air quality standards, incorporate protections for people with respiratory diseases, such as asthma and pesticide regulations provide additional protections for children. Place an Order 3,00,000 Rupees for Phase I (human) clinical trials Assignment on International Trade: Barriers and facilitation. Regulations in the U.S. do this to some degree. The Environmental Protection Agency (EPA) is an independent executive agency of the United States federal government tasked with environmental protection matters. The country is a federal republic composed of 26 cantons, with federal authorities based in Bern. 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